Publications

Hepatology International, January 2018

Translating scientific discovery: the need for preclinical models of nonalcoholic steatohepatitis.

Expert Opinion on Drug Discovery, November 2017

Non-Alcoholic fatty liver disease (NAFLD) models in drug discovery

STEM CELLS Translational Medicine (SCTM), June 2017

Exposure of iPSC-derived vascular endothelial and smooth muscle cells in co-culture to hemodynamics induces primary vascular cell-like phenotypes

JCI Insight, December 2016

Development of an In Vitro Human Liver System for Interrogating Non-Alcoholic Steatohepatitis

Thrombosis Research, April 2016

Hemodynamics associated with atrial fibrillation directly alters thrombotic potential of endothelial cells.

Molecular Genetics Metabolism, December 2015

Recapitulation of metabolic defects in a model of propionic acidemia using patient-derived primary hepatocytes.

Chemical Biological Interactions, November 2015

Transcriptional profiling suggests that Nevirapine and Ritonavir cause drug induced liver injury through distinct mechanisms in primary human hepatocytes.

Arteriosclerosis, Thrombosis, Vascular Biology, August 2015

An In Vitro Cynomolgus Vascular Surrogate System for Preclinical Drug Assessment and Human Translation.

American Journal of Physiology – Cell Physiology, June 2013
Hemodynamic Flow Improves Rat Hepatocyte Morphology, Function, and Metabolic Activity In Vitro

Nature Communications, April 2013
Human Hemodynamic Frequency Harmonics Regulate the Inflammatory Phenotype of Vascular Endothelial Cells

Journal of Clinical Investigation, December 2012
Endothelial Kruppel-like Factor 4 Protects Against Atherothrombosis in Mice

Expert Opinion on Drug Metabolism and Toxicology, August 2012
Organotypic Systems in Drug Metabolism and Toxicity: Challenges and Opportunities

Public Library of Science, May 2012
Matrix Rigidity Regulates Cancer Cell Growth by Modulating Cellular Metabolism and Protein Synthesis

Arteriosclerosis, Thrombosis, and Vascular Biology, July 2011
Hemodynamic Activation of β-catenin and TCF Signaling in Vascular Endothelium Regulates Fibronectin Expression

Circulation Research, April 2010

Atheroprone Hemodynamics Regulate Fibronectin Deposition to Create Positive Feedback That Sustains Endothelial Inflammation.

Arteriosclerosis, Thrombosis, and Vascular Biology, February 2009

Human IL-8 regulates smooth muscle cell VCAM-1 expression in response to endothelial cells exposed to atheroprone flow.