Customer Applications

To date, HemoShear has created and validated a healthy large artery system, a healthy arteriole system, an atherosclerotic large artery system, and a hypertensive large artery system. Work is planned for a diabetic micro-vascular system, a diabetic large artery system, and a healthy liver system. In addition, the HemoShear technology has been used to develop species-specific systems.

Shown below are some examples of how the HemoShear technology has been applied to specific programs on behalf of our customers:

• Genome-wide profiling for vascular inflammation and hypertensive disease targets
• Creation of an inflammation surrogate system for target identification & validation
• Validation of a target that plays a key role in vascular wall homeostasis
• Specific cell surface quantification/turnover for a biologics target and computational analyses for “coverage” assessment for atherosclerosis
• Functional assessments of vascular permeability and monocyte adhesion
• Differentiate the hypertensive effects of four compounds
• Validate use of permeability systems to de-risk clinical vascular edema of a specific compound class
• Safety assessment and predictive system for flow-mediated effects of compound and drug-induced vascular injury in a small animal artery system