Drug Candidates
This is the preliminary list of drugs HemoShear intends to test in its human vascular system. This list may change based on input from the External Program Scientific Advisory Board and the Industry Advisory Board.
| DRUG | TARGET | TARGET ORGAN/REGION |
|---|---|---|
| carvedilol | non-selective beta blocker, weak alpha1 blocker | blood vessels, heart |
| metoprolol | beta1 receptor blocker | blood vessels, heart |
| bisoprolol | beta1 receptor blocker | blood vessels, heart |
| propranolol | non-selective beta blocker | blood vessels, heart |
| bucindolol | non-selective beta blocker, weak alpha1 blocker | blood vessels, heart |
| timolol | non-selective beta blocker | blood vessels, heart |
| nadolol | non-selective beta blocker | blood vessels, heart |
| nifedipine | dihydropyridine calcium channel blocker | blood vessels |
| nisoldipine | dihydropyridine calcium channel blocker | blood vessels |
| nicardipine | dihydropyridine calcium channel blocker | blood vessels |
| verapamil | voltage-dependent calcium channel blocker | blood vessels, heart |
| diltiazem | calcium channel blocker | blood vessels, heart |
| torcetripib | CETP inhibitor for atherosclerosis | plasma |
| anacetrapib | CETP inhibitor for atherosclerosis | plasma |
| dalcetrapib | CETP inhibitor for atherosclerosis | plasma |
| imipramine | tricyclic antidepressant | neurotransmitter systems |
| desipramine | tricyclic antidepressant | neurotransmitter systems |
| amitryptiline | tricyclic antidepressant | neurotransmitter systems |
| paroxitine | SSRI antidepressant | neurotransmitter systems |
| escitalopram | SSRI antidepressant | neurotransmitter systems |
| propoxyphene | narcotic analgesic | brain/CNS |
| morphine | narcotic analgesic | CNS |
| fentanyl | narcotic analgesic | spinal cord/CNS |
| dynorphin | opioid peptide class | CNS/PNS |
| estrogen | HRT and contraception | uterus, pituitary gland |
| progesterone | HRT and contraception | uterus |
| estrogen-progesterone combination | HRT and contraception | uterus, pituitary gland |
| atorvastatin | HMG-CoA reductase inhibitor | liver |
| pravastatin | HMG-CoA reductase inhibitor | liver |
| lovastatin | HMG-CoA reductase inhibitor | liver |
| simvastatin | HMG-CoA reductase inhibitor | liver |
| cerivastatin | HMG-CoA reductase inhibitor | liver |
| pioglitazone | Insulin sensatizer via PPARγ | liver, muscle, adipose tissue |
| rosiglitazone | Insulin sensatizer via PPARγ | liver, muscle, adipose tissue |
| troglitazone | Insulin sensatizer via PPARγ and PPARα | liver, muscle, adipose tissue |
| rofecoxib | COX-2 inhibitor | inflamed tissue |
| acetominophen | non-selective COX inhibitor | inflamed tissue |
| naproxen | non-selective COX inhibitor | inflamed tissue |
| celecoxib | COX-2 inhibitor | inflamed tissue |
| aspirin | non-selective COX inhibitor | inflamed tissue |
| ibuprofen | non-selective COX inhibitor | inflamed tissue |
| captropril | ACE inhibitor | blood vessels, heart, adrenal glands, kidney |
| losartan | Ang II receptor antagonist | blood vessels, heart |
| sitagliptin | DPP4 inhibitor | pancreas |
| vildagliptin | DPP4 inhibitor | pancreas |
| saxagliptin | DPP4 inhibitor | pancreas |
| dapagliflozin | SGLT2 inhibitor | kidney |
| canagliflozin | SGLT2 inhibitor | kidney |
| diuretic-CCB combination | antihypertensive | |
| diuretic-beta blocker combination | antihypertensive | |
| diuretic-ACE combination | antihypertensive | |
| diuretic-ARB combination | antihypertensive |