Proof of Concept
During the last ten years, HemoShear’s technology has been validated in 15 peer-reviewed publications. The technology has reliably and accurately replicated human response in over 3000 experiments and using over 800 human donors. Extensive proof-of-concept studies have been conducted with the HemoShear technology to validate that the technology is able to reliably and consistently replicate human (and animal) in-vivo conditions:
| Parameters | Peer-Reviewed Publications |
|---|---|
| Vascular Cell Biology Artery Structure Endothelial Cell Function Smooth Muscle Cell Function Regional Hemodynamics Differentially Regulate Cell Phenotypes Disease-Prone Hemodynamic Flow Creates Athero-Prone Cell Phenotype Inflammation & Inflammatory Response Extracellular Matrix, Fibronectin Biology Novel Interleukin-8 Biology Endothelial Barrier Function ER Stress Biology in Atherosclerosis Endothelial Capillary Sprouting | Gelfand et al., J Magn Reson Imaging, 2006 Simmers, et al., AJP Heart Circ Phys, 2007 Orr et al., J Cell Biol, 2007 Hastings, et al., AJP Cell Phys, 2007 Anderson, et al., Am J Path, 2008 Harry et al., ATVB, 2008 Feaver, et al., ATVB, 2008 Thomas et al., Am J Physiol Heart Circ Physiol, 2009 Jin et al., J Muscle Res Cell Motil, 2009 Hastings, et al., ATVB, 2009 Feaver, et al., Circ Res, 2010 |
Studies that have been performed to validate the effects of drugs in the HemoShear technology correlate with published clinical evidence, including:
- Atorvastatin's Anti-Inflammatory Effects and Barrier Function Enhancement
- Rofecoxib’s Inflammatory Properties
- Pioglitazone’s Anti-Inflammatory Effects
- Minoxidil Response in Rodents versus Humans
- Simvastatin’s Anti-Hypertensive Effects
- Amlodipine Effects on Barrier Function/Peripheral Edema
- NO-Donor’s Anti-Hypertensive Effects
- Thrombin’s Effects on Barrier Function
- Industrial Chemical's Effects on Barrier Function
These studies confirm that HemoShear’s technology can reliably and consistently produce results which robustly represent the in-vivo biological response of animal or humans cells.